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« Back to Contents MISCELLANEOUS

LiFE re

Literature for ENYGO

Treatment of elderly patients with gynaecological cancers

Editor Alex Mutombo

Descriptive summary the younger patients. That did not translate into prolonged hospi-
tal stays or excessive complications. They concluded that earlier
Age induces a progressive decline in functional reserve and impacts intervention with physical therapy and stool softeners could possibly
cancer treatments. Endometrial and ovarian cancer primarily affects close this gap in recovery.
elderly women. In addition, clinical trial data are limited for elderly
patients because approximately one third of the elderly women who Moreover, Zhou et al. conducted a study to evaluate the effects of
meet pathologic enrolment criteria for trials are excluded because age and the clinical response to neoadjuvant chemotherapy (NACT)
of complex medical disease. Clark et al. performed a retrospective in patients with cervical cancer who received neoadjuvant chemo-
chart review of all endometrial cancer cases from a tertiary care therapy followed by radical surgery. They found that responders to
institution from 2005 to 2010 and found that more adjuvant treat- NACT aged 35 years or younger benefitted the most from NACT,
ment was recommended in the elderly patients because of a higher while the young non-responders benefitted the least. Hence, age
incidence of advanced disease and aggressive histopathology. might represent an important factor to consider when offering neo-
Approximately only half of those who were recommended treatment adjuvant chemotherapy in patients with cervical cancer.
actually received it.
Some studies by Lin et al. in the United States and Or Knudsen in
Fourcadier et al. found that elderly women with ovarian cancer were Denmark have focused on overall survival in women with gynaeco-
therapeutically disadvantaged compared to younger women. This logic cancer. The main conclusion was that both mortality rates and
was confirmed by Peled et al. when they compared postoperative survival are age-dependent, with a significantly shorter survival in
recovery between elderly patients and younger patients after lapa- the elderly group.
rotomy for endometrial cancer staging. According to their study, the
elderly ambulated later and recovered bowel function later than did

Relevant articles retrieved Nov 2015 - Feb 2016

No Title Authors Journal Link to abstract

1 Telomere length is a prognostic biomarker in elderly advanced ovarian cancer Falandry C et al. Aging (Albany NY). http://www.ncbi.nlm.nih.gov/
patients: a multicenter GINECO study. BMC Cancer. pubmed/26638179
Am J Obstet Gynecol.
2 Under-treatment of elderly patients with ovarian cancer: a population based Fourcadier E et al. Cancer Epidemiol Biomarkers http://www.ncbi.nlm.nih.gov/
study. Prev. pubmed/26610814
Eur J Surg Oncol.
3 Comparative outcomes in older and younger women undergoing laparotomy Guy MS et al. Int J Gynecol Cancer. http://www.ncbi.nlm.nih.gov/
or robotic surgical staging for endometrial cancer. Obstet Gynecol. pubmed/26433173
Acta Oncol.
4 Association between Metformin Use and Mortality after Cervical Cancer in Han K et al. PLoS One. http://www.ncbi.nlm.nih.gov/
Older Women with Diabetes. Int J Gynecol Cancer. pubmed/26721670
Obstet Gynecol.
5 Endometrial cancer in elderly women: Which disease, which surgical man- Bourgin C et al. http://www.ncbi.nlm.nih.gov/
agement? A systematic review of the literature. pubmed/26647302

6 Adjuvant Treatment and Clinical Trials in Elderly Patients With Endometrial Clark LH et al. http://www.ncbi.nlm.nih.gov/
Cancer: A Time for Change? pubmed/26745698

7 Ovarian Cancer Treatment and Survival Trends Among Women Older Than 65 Lin JJ et al. http://www.ncbi.nlm.nih.gov/
Years of Age in the United States, 1995-2008. pubmed/26646132

8 Trends in gynecologic cancer among elderly women in Denmark, 1980-2012. Or Knudsen A et al. http://www.ncbi.nlm.nih.gov/
pubmed/26784001
9 Young Cervical Cancer Patients May Be More Responsive than Older Patients Zhou J et al.
to Neoadjuvant Chemotherapy Followed by Radical Surgery. http://www.ncbi.nlm.nih.gov/
pubmed/26901776
10 Endometrial Cancer Surgery for Elderly Women--The Early Postoperative Peled Y et al.
Period. http://www.ncbi.nlm.nih.gov/
pubmed/26332393
11 Management for Elderly Women With Advanced-Stage, High-Grade Endo- Rauh-Hain JA et al.
metrial Cancer. http://www.ncbi.nlm.nih.gov/
pubmed/26551187

International Journal of Gynecological Cancer, Volume 26, Supplement #1 Page 66