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LiFE re

Literature for ENYGO

Cancer in pregnancy

Editor Michael J. Halaska chosen for the treatment of B-cell NHL after the first trimester. For
chronic myeloid leukaemia, IFN α is considered safe during pregnancy
Descriptive summary while TKI are not recommended. For acute leukaemias the treatment
options are less available due to the teratogeneity of most agents
In total, six publications have been published within the selected used, therefore when diagnosed before the 20th week of pregnancy,
period. They consist of several case reports on ocular melanoma, a termination is usually proposed. Additionally, a disseminated intra-
oesophageal carcinoma, and metastatic breast carcinoma. An vascular coagulopathy should be prevented in specific haematologic
Italian group published a series of 6 patients with tongue cancer, malignancies during pregnancy.
which presented a 50 % mortality rate. A Korean set of patients
described single-centre data on 87 women diagnosed with cancer
and pregnancy. The incidence of cancer were, in descending order,
breast cancer, gastrointestinal cancer, haematologic malignancies,
thyroid cancer, central nervous system tumours, and lastly cervical,
ovarian, and lung cancer. In 20.7 %, the pregnancy was terminated,
while others opted to retain the pregnancy. The mortality rate was
31 %, with the highest rates in patients with lung, gastrointestinal,
haematologic, and breast cancer.

JCO published international guidelines for management of hemato-
logic malignancies during pregnancy. The most common malignancy
is Hodgkin disease, which usually has an excellent prognosis. Typi-
cally, it can be treated by ABVD during the second and third trimes-
ters. There is insufficient data about BEACOPP during pregnancy. For
non-Hodgkin disease, steroids could be used in the first trimester,
while chemotherapy could be administered during the second and
third trimesters. Increasing data suggests that rituximab could be

Relevant articles retrieved Nov 2015 - Feb 2016

No Title Authors Journal Link to abstract
Tagliabue M et al. Crit Rev Oncol Hematol.
1 Tongue cancer during pregnancy: Surgery and more a multidisciplinary http://www.ncbi.nlm.nih.gov/
challenge. Shim MH et al. Obstet Gynecol Sci. pubmed/26476748

2 Clinical characteristics and outcome of cancer diagnosed during pregnancy. J Clin Oncol. http://www.ncbi.nlm.nih.gov/
pubmed/26866029
3 Hematologic Malignancies in Pregnancy: Management Guidelines From an Lishner M et al.
International Consensus Meeting. http://www.ncbi.nlm.nih.gov/
pubmed/26628463

International Journal of Gynecological Cancer, Volume 26, Supplement #1 Page 61